For a better experience, click the Compatibility Mode icon above to turn off Compatibility Mode, which is only for viewing older websites.

Nianli Sang, M.B., Ph.D.

Nianli Sang, PhD

Associate Professor
Department of Biology
Office: PISB 417
nianli.sang@drexel.edu
Phone: 215.895.6885
Lab Location: PISB 401 H2
Lab Phone: 215.895.1436

Education:

  • Bachelor of Medicine, Fudan University, Shanghai Medical College, China, 1982-1988
  • Master of Surgery (Residency), Zhongshan Hospital, Fudan University, Shanghai Medical College, China, 1988-1992
  • PhD, Genetics, Thomas Jefferson University, Kimmel Cancer Center, 1992-1997
  • Post-doctoral training, University of Pennsylvania School of Medicine, Institute of Human Gene Therapy, 1997-1999
  • Post-doctoral training, Thomas Jefferson University Hospital, Cardeza Foundation for Hematological Research, 2000-2003

Research Interests:

再保险

Sp

Prior Research Funding:

R01-CA129494
9/18/2008-7/31/2013
NIH/NCI
Total Award: $1,563,600
“Repressing HIF-1: targets and mechanisms”
Role: PI

Selected Publications:

  • Meng, M., Chen, S., Lao, T., Liang, D., and *Sang, N. (2010) Nitrogen Anabolism underlies the glutaminolysis in proliferating cells. Cell Cycle, 9(19): 3921 - 3932.
  • Stiehl, D.P, Fath, D.M., Liang, D.M., Jiang, Y.B., and *Sang, N. (2007) Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation. Cancer Res., 67(5): 2276-2286.
  • Fath, D.M., Kong, X., Liang, D., Lin, Z., Chou, A., Jiang, Y., Fang, J., Caro, J. and *Sang, N. (2006) Histone deacetylase inhibitors repress the transactivation potential of hypoxia inducible factors independently of direct acetylation of HIF-??? J. Biol. Chem., 281:13612-13619.
  • Kong, X., Lin, Z., Liang, D., Fath, D., *Sang, N., and *Caro, J. (2006) Histone-deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of HIF-1?. Mol. Cell Biol., 26:2019-2028.
  • *Sang, N., Stiehl, D.P. Bohensky, J., Leshchinsky, I., Srinivas, V., and *Caro, J. (2003) MAPK Signaling Up-regulates the activity of hypoxia-inducible factors by its effects on p300. J. Biol. Chem., 278: 14013-14019.
  • Sang, N., Fang, J., Srinivas, V., Leshchinsky I., and *Caro, J. (2002) Carboxyl terminal transactivation activity of HIF-1? is governed by a VHL-independent, hydroxylation-regulated, association with p300/CBP. Mol. Cell. Biol., 22:2984-2992.
(*As corresponding author)