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Lawrence Bergman

Lawrence Bergman, PhD

Professor Emeritus


Department: Microbiology & Immunology

Education

  • PhD - University of Virginia (1979)

Lawrence Bergman, PhD, is a professor in the Department of Microbiology & Immunology at Drexel University College of Medicine.

Research Interests

Malaria, invasion, global gene expression, merozoite, sporozoite, actin-myosin, microarray, Plasmodium

Research

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Publications

Selected publications
(See all Lawrence Bergman's publications in PubMed.)

"Characterization of a Plasmodium falciparum orthologue of the yeast ubiquinone-binding protein, Coq10p"
Jenkins BJ, Daly TM, Morrisey JM, Mather MW, Vaidya AB and LW Bergman
PLoS One
, e0152197, 2016

Host erythrocyte environment influences the localization of exported protein 2, an essential component of the Plasmodium translocon
Meibalan E, Comunale MA, Lopez AM, Bergman LW, Mehta A, Vaidya AB and  JM Burns Jr., >
Eukaryot Cell. 14:371-384, 2015

"Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum"
Vaidya AB, Morrisey JM, Zhang Z, Das D, Daly TM, Otto TD, Spillman NJ, Wyvatt M, Siegl P, Marfurt J, Wirjanata G, Sebayang BF, Price RN, Chatterjee A, Nagle A, Stasiak M, Charman SA, Angulo-Barturen I, Ferrer S, Belen Jimenez-Diaz M, Martinez MS, Gamo F, Avery VM, Ruecker A, Delves M, Kirk K, Berriman M, Kortagere S, Burrows J, Fan E and LW Bergman
Nat. Commun. 5:5521, 2014

The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody
Khamrui S, Turley S, Pardon E, Steyaert J, Fan E, Verlinde CL, Bergman LW and WG Hol
Mol Biochem Parasitol. 190:87-91, 2013

The compact conformation of the Plasmodium knowlesi myosin tail interacting protein MTIP in complex with the C-terminal helix of myosin A
Turley S, Khamrui S, Bergman LW and WG Hol
Mol Biochem Parasitol. 190:56-59, 2013

"Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials"
Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW and DC Greenbaum
Cell Host Microbe, 12: 815-823, 2012.

"Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria"
Cernetich-Ott A, Daly TM, Bergman LW and JM Burns, Jr.
Malar. J., 11: 265, Epub ahead of print, 2012.

"Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum"
Bosch J, Paige MH, Vaidya AB, Bergman LW and WG Hol
J. Struct. Biol., 178: 61-73, 2012.

Elevated levels of the Plasmodium yoelii homologue of macrophage migration inhibitory factor attenuate blood-stage malaria.
Thorat S, Daly TM, Bergman LW and Jr. Burns JM.
Infection and Immunity, 78: 5151-5162, 2010.

Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum
Kortagere S, Welsh WJ, Morrisey JM, Daly T, Ejigiri I, Sinnis P, Vaidya AB and Bergman LW.
Journal of Chemical Information and Modeling, 50: 840-849, 2010.

High mobility group protein HMGB2 is a critical regulator of plasmodium oocyst development.
Gissot M, Ting LM, Daly TM, Bergman LW and Sinnis P.
Journal of Biological Chemistry., 283: 17030-17038, 2008.

Functional characterization of a redundant Plasmodium TRAP family invasin, TRAP-like protein, by aldolase binding and a genetic complementation test.
Heiss K, Nie H, Kumar S, Daly TM, Bergman LW and Matuschewski K.
Eukaryotic Cell, 7: 1062-1070, 2008.

Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host.
Mikolajczak SA, Silva-Rivera H, Peng X, Tarun AS, Camargo N, Jacobs-Lorena V, Daly TM, Bergman LW, de la Vega P, Williams J, Aly AS and Kappe SH.
Molecular and Cellular Biology., 28: 6196-6207, 2008.

A combined transcriptome and proteome survey of malaria parasite liver stages.
Tarun AS, Peng X, Dumpit R. F, Ogata Y, Silva-Rivera H, Camargo N. Daly TM, Bergman LW and Kappe SH.
Proceedings of the National Academy of Sciences of the United States of America. 105: 305-310, 2008.

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.
Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Zhou N, Morrisey JM, Vaidya AB, Bergman LW and Hol WG J.
Proceedings of the National Academy of Sciences of the United States of America, 103: 4852-4857, 2006.


Contact Information


Department of Microbiology & Immunology
2900 W. Queen Lane
Philadelphia, PA 19129
Phone: 215.991.8376
Fax: 215.848.2271