The following are posters produced by students in the Pathologists' Assistant (PathA) program.
Dissecting Ergonomics: Personalized Strategies at the Grossing Bench
Student:
Lucie Bennett-Stein
About the Poster:
Analyzing and processing surgical specimens at the grossing bench presents unique ergonomic challenges specific to the Pathologists’ Assistants craft. Repetitive tasks and improper posturing lead to chronic musculoskeletal disorders, adversely affecting individual wellness. While recent studies have focused on assessing ergonomics within clinical laboratory professions, they often overlook the nuances of grossing specimens at a pathology bench. This research aims to compile and draw attention to personalized methods utilized by current Pathologists’ Assistants to mitigate the risk of work related injuries. Additionally, it seeks to educate both current and future pathology professionals on personalized ergonomic options for their own safety.
A survey was conducted of current Pathologists’ Assistants across the United States to gauge their knowledge of ergonomics and assess their workspaces, providing insights into personalized solutions for addressing ergonomic challenges within the gross lab. Results indicate a range of customizable products and practices for creating functional ergonomic environments tailored to the individual. By promoting awareness of available tools and equipment to improve ergonomics, this research strives to safeguard the long-term health of Pathologists’ Assistants and improve safety outcomes within the grossing profession.
Back to Top
Lost Voice: A Case Study on Recurrent Laryngeal Squamous Cell Carcinoma Resulting in a Total Laryngectomy and Partial Pharyngectomy
HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Student:
Brittany Schleeter
About the Poster:
Oropharyngeal squamous cell carcinoma (OPSCC) accounts for 90% of all malignancies of the oral cavity. It is strongly linked to alcohol consumption, cigarette smoking and infection with high-risk human papillomavirus (HPV) strains 16 and 18. If detected early, oropharyngeal squamous cell carcinoma can often be resected and many patients reach remission, with an overall 5-year survival rate of 68.5%; however, when OPSCC is detected in later stages, it can often lead to large, complex resections with multiple recurrences of disease.
Back to Top
Beyond Acute Appendicitis: Mucinous Neoplasm Presenting as Appendiceal Mucocele: A Case Study
An Overview of Jelly Belly Syndrome (Pseudomyxoma Peritonei)
Student:
Brittany Schleeter
Ab
Although uncommon to receive an AMN with a clinical history of PMP, it is essential for pathologists’ assistants (PAs) to be comfortable accessioning and grossing these specimens. Familiarity with both the gross and histological features of pseudomyxoma peritonei ensures that PAs will save the appropriate tissue for cytological, molecular, and genetic testing as well as submit pertinent sections for microscopic review; however, PMP can be intimidating. Literature regarding pseudomyxoma peritonei is often contradictory and the classification of PMP only recently became standardized. The goal of this poster is to present a clear, concise overview of pseudomyxoma peritonei in order to improve pathologists’ assistants’ understanding of this rare pathological syndrome.
Back to Top
Biomarkers of Alzheimer’s Disease
Student:
Monet Kumazawa
About the Poster:
Alzheimer’s disease is the most common type of dementia, presenting as mild memory loss and resulting in progressive loss of ability to carry out daily activities. Gross pathology shows enlarged ventricles and a shrunken hippocampus. Microscopic examination reveals an accumulation of insoluble fibrous material with extracellular amyloid and neurofibrillary tangles (NFT). Societally, Alzheimer’s disease is a puzzling degenerative neurologic disorder that we still have no clinical treatment for or an official metric for pre-clinical diagnosis.
Back to Top
Multifocal Osteosarcoma: Multiple Primaries or Metastasis?
Student:
Megan Kwan
Contributor:
Mande Beers, MHS, PA(ASCP), Ivan Gonzales, MD and Jennifer Pogoriler, MD, PhD – Children’s Hospital of Philadelphia
Ab
Back to Top
No Womb For Error: A case study demonstrating adequate specimen sampling, despite a distracting pathology
Student:
Emily Amato
Contributor:
Shaymaa Ashi, MD, St. Luke’s University Hospital, Bethlehem, Pa.
About the Poster:
Primary fallopian tube carcinoma is rare and often already invasive at the time of diagnosis. The following case is that of a woman who presented with postmenopausal bleeding, believed to be attributed to a very large and likely benign endometrial polyp. Since the protocol for grossing a TLH-BSO specimen involves heavy sampling of the fallopian tubes and ovaries, the pathologist was able to discover multifocal invasive and metastasizing serous carcinoma, originating from the fallopian tube.
Back to Top
Cause of Death Due to Complications of Lipomatous Hypertrophy of the Interatrial Septum
Student:
Sarah Lock
Contributor:
Khalil Wardak, MD
About the Poster:
Lipomatous hypertrophy of the interatrial septum (LHIS) is a benign condition characterized by the accumulation of adipose tissue in the interatrial septum, which spares the fossa ovalis. While LHIS is not a true tumor, it should be considered in the differential diagnosis when an adipose cardiac tumor, such as a cardiac lipoma, is discovered. Most cardiac tumors are benign, and many are incidentally diagnosed upon autopsy. However, due to the location and size, benign cardiac tumors may impede blood flow and cause arrhythmias, leading to death. We report the case of a woman who died due to complications of previously-undiscovered LHIS.
Back to Top
Following the Flame: Amputations in Burn Victims
Student:
Lauren E. Nerotto, Pathologists’ Assistant Student, Drexel University College of Medicine, Philadelphia, PA
Contributor:
Judy Pascasio, MD , St. Christopher’s Hospital for Children, Philadelphia, PA
About the Poster:
Infection, sepsis, tissue necrosis and decreased blood volume are just some of the life-threatening factors to consider when treating severely burned patients. Electrical burns are much more common in young men but overall are a relatively rare pathology. For many patients, amputations are a measure used to remove gangrenous and infected tissue thereby increasing the patients’ chance of survival.
Back to Top
It’s Gross to Me: The role of the PA in diagnosing a renal cell carcinoma, clear cell type with rhabdoid differentiation
Student:
Taylor Marvin
Contributor:
Angela Pietsch, PA(ASCP), Paoli Hospital, Paoli, Pa.
About the Poster:
Renal cell carcinoma (RCC), clear cell type with rhabdoid differentiation is an uncommon, aggressive tumor most commonly found in adult men over the age of 40. The rhabdoid component of the tumor is thought to be due to dedifferentiation of the parent cells and can present in other types of renal cell carcinomas, though it is most often associated with clear cell type. These tumors usually present with minimal symptoms and metastasize quickly, making it difficult to identify and treat the tumor. The late presentation, low incidence of this tumor, and aggressive nature have made it a challenge to establish a standard treatment for this tumor type, and studies have shown minimal success in reduction of mortality with various treatment options.
Back to Top
Hepatocellular Carcinoma Presenting as Right Atrial Mass
Student:
Mary Erdman
Mentors:
Abington Hospital-Jefferson Health
Kathleen Brown, PA (ASCP)CM
Karen Bell, MD
Ab
Back to Top
A Pathologists' Assistant's Critical Role in the Proper Diagnosis of Gastroschisis and Trisomy 18
Student:
Lindsey Wilson
Mentors:
Kelly Menges, PA(ASCP)-Abington Memorial Hospital
About the Poster:
Although gastroschisis is a frequently studied abdominal wall defect, it continues to be researched as many believe the condition has an environmental component. Unlike omphalocele, a similar abdominal wall defect, the organs are not covered by a protective sac. Thus, the severity of gastroschisis depends on the number of protruding organs as well as the duration they are exposed for. In this particular case, a woman from Brazil presented to a hospital in Pennsylvania for a follow-up on the condition of her fetus. Through techniques such as gross and microscopic dissection, as well as microarray testing, her fetus was discovered to have gastroschisis and trisomy 18. Read more.
Back to Top
Mixed Germ Cell Tumor with Predominate Choriocarcinoma in Testicle
Student:
Kelly Hollar
Mentors:
Kelly Menges, PA(ASCP)-Abington Memorial Hospital
About the Poster:
Testicular germ cell tumors (GCTs) cause approximately 10% of all cancer deaths in men 15- 34 years old and are a histologically diverse category of neoplasms that consist of a mixed cell type in 40- 45% of cases. Choriocarcinoma is the rarest and most highly malignant subtype of GCT and can present with diffuse metastasis at the time of diagnosis. It is found as the only cellular subtype in less than 1% of all GCTs and is found as a component in only eight- 10% of mixed GCTs. Here, a case of mixed GCT comprised of >95% choriocarcinoma, presents as a painless testicular growth with lung and lymphatic metastasis. The patient’s prognosis and treatment are dependent not only tumor invasion but on proper identification of each histologic subtype. The pathologist assistants’ care in selecting sections is vital.
Back to Top
Dedifferentiated Liposarcoma of the Proximal Lower Extremity
Student:
Britni Stowell
Mentors:
James W. Moore, PA(ASCP)CM
Dr. Edina Grujic, MD - Bryn Mawr Hospital
About the Poster:
The patient is an 81 year old male who first presented in May 2019 with a sizeable mass on the left anterior thigh, which is grossly visible. The patient states that the mass is not painful and has been growing for the last two years. He has decided to seek medical attention due to his recent significant weight loss and fatigue. Upon palpation the mass is nontender. There is no weakness of the leg, no tingling or neurological defects, and no regional lymphdenopathy. In addition the patient has an extensive medical history including GERD, hypertension, multiple heart surgeries, BPH, hernias, and multiple melanoma excisions from the scalp and left hand in 2015. The patient has no family history of other malignancies or soft tissue masses.
Back to Top
How to Gross a Female Pelvic Exenteration for Advanced Sigmoid Colon Cancer
Student:
Kelly Baxter, HT (ASCP)CM, PA (ASCP)*
Mentors:
David Beckles, PA (ASCP)CM
Annabel Canhao, PA (ASCP)CM
About the Poster:
Colorectal cancer is the most common gastrointestinal malignancy and contributes to nearly 10% of all cancer deaths, second only to lung cancer. North America has the highest incidence and disease peaks between 60 to 70 years of age. Colonic adenocarcinomas are distributed along the length of the colon, growing as exophytic masses in the proximal colon and annular, constricting lesions in the distal colon. Colon adenocarcinoma most commonly metastasizes to the liver as a result of portal drainage, but may also metastasize to regional lymph nodes, lungs and bones.
Back to Top
Familial Adenomatous Polyposis: A Review of Treatment and Associated Syndromes
Student:
Steven M. Vanko MS, PA
Mentors:
Sarra-Valentina Klimberg, MS, PA (ASCP)cm
Katrina A. Conard, MD
About the Poster:
Familial adenomatous polyposis is (FAP) is a rare and largely inherited cancer predisposition syndrome5. FAP occurs in around 1 in 10,000 people1. With this condition, individuals will develop numerous, precancerous adenomatous polyps throughout their colon and rectum1. The polyps start to develop in the teen years to early 20’s (mean age of 16), and by 35 years old, 95% of patients will have polyps5. With age these polyps will increase in number and in size, and eventually one of these polyps will become cancerous. In fact, colon cancer is inevitable without colectomy, and adenocarcinoma develops at a mean age of 39 in untreated patients2.
Back to Top
Invasive Squamous Cell Carcinoma of the Cervix
Student:
Brian Chase
Mentors:
David Kirschenmann, PA (ASCP)
Pradeep K. Bhagat, MD, Lankenau Medical Center
About the Poster:
The patient is a 46-year-old female who presented with a large, exophytic cervical lesion upon physical examination by her physician. A PET-CT scan was performed to confirm the presence of the cervical lesion and positive pelvic lymph nodes. The patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection to be followed by chemotherapy and radiation.
Back to Top
Neuropathologic Changes of Alzheimer Disease: A Case Study
Student:
Mark Vincent C. Olorvida, MHS
Faculty:
Christos D. Katsetos, MD, PhD, FRCPath, Ahmed Abdulrahman, MD, Drexel University College of Medicine, Philadelphia, Pa.
About the Poster:
A 66-year-old Caucasian woman presented with a history of depression, anxiety, and dementia for about 2 years. She demonstrated multiple cognitive difficulties including memory deficit, and she later became more confused, agitated, and at times, delusional. She was employed at a bank, but lost her ability to do simple mathematics. For the last year of her life, her skills with a variety of motor functions declined. Her walk became unsteady and she started to have frequent falls and gait dysfunction. She frequently experienced right-sided headaches and her behavior progressively changed with psychotic symptoms.
Back to Top
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins: An Autopsy Case Report
Student:
Kevin O'Connor
Faculty:
Jeanine Chiaffarano, DO, University of Medicine and Dentistry of New Jersey
Marta Guttenburg, MD, The Children's Hospital of Philadelphia
About the Poster:
This is the case of a 13-day-old female infant delivered at 34 2/7 weeks to a 38-year-old G1P0 mother with spontaneous rupture of membranes, via cesarean section on 2/26. Prenatally, the infant was diagnosed with an omphalocele and a 17q12 duplication encompassing the HNF1B gene; the karyotype was normal female.
Back to Top
An Interesting Case of Colorectal Cancer Metastasis
Students:
Molly C. Pitluck, BS, PA (ASCP)
Steve Sowers, BS, PA (ASCP)
Faculty:
Sharon L. Swierczynski, MD, PhD, The Reading Hospital and Medical Center, Reading, Pa.
About the Poster:
In January 2013, a 64-year-old white male presented with chief complaints of right tibia and ankle pain as well as open wounds in his right lower leg for the last couple of months. The patient's past medical history was significant for poorly differentiated infiltrating adenocarcinoma of the rectosigmoid colon (PT3C/D), status post partial colectomy in 2007; metastatic adenocarcinoma to the right distal tibia, consistent with a colon primary (CEA, CK20, CDX2 positive; CK7, TTF-1 negative), in 2009, status post prophylactic rodding in 2011; and metastatic adenocarcinoma to right groin lymph nodes consistent with a colon primary, status post excision in 2010. Additional PMH included hypertension, hypercholesterolemia, status post appendectomy in 1961, history of detached retina in 1990, and status post left ankle fracture in 1998.
Back to Top
A Case of Extramammary Paget Disease: Determining Primary or Secondary Origin
Student:
Molly Lundy
Faculty:
Dr. Adamec and Dr. Kimmel, The Reading Hospital and Medical Center, Reading, Pa.
About the Poster:
Extramammary Paget Disease (EMPD) is a malignant and destructive skin lesion often seen in concurrence with an underlying malignancy (such as in the more common mammary type), but can also arise de novo4,6. These primary lesions are commonly found in areas rich in apocrine sweat glands such as the vulva, perianal region, axilla, mons pubis, glans penis and eyelid4 (listed in order of occurrence). There are multiple hypotheses for this presentation. Two common understandings are that it appears as an epidermotrophic metastasis from a visceral carcinoma, commonly uterine or rectal, or within the skin arising from apocrine derivation. It is important to determine the derivation of an extramammary case in order to rule out an undiagnosed underlying visceral carcinoma.
Back to Top
Male Breast Cancer
Student:
Anthony Pinto, MS, PA (ASCP)
Faculty:
Suresh Majmundar, PA (ASCP)
Corrado Minimo, MD, Albert Einstein Medical Center
About the Poster:
Breast cancer is much less common in men than in women. Male patients are older and show more advanced disease at the time of clinical presentation. Furthermore, invasive ductal carcinoma predominates in men >90% of the time, while ductal carcinoma in-situ (DCIS) and lobular carcinomas are less common or rare in comparison with women.
Back to Top
Malignant Paraganglioma of the Thyroid Gland: A Case Study
Metastatic Prostate Adenocarcinoma: Oh the Places It Goes
Student:
Brian Hoffman, MS, PA (ASCP)
Faculty:
Joseph A. DiRienzi, PA (ASCP)
Igor Tsimberg, PA (ASCP)
Grant Nybakken, MD, PhD
Charuhas Deshpande, MD
About the Poster:
Adenocarcinoma of the prostate is the most common form of cancer in men, typically affecting men over the age of 50. The etiology of prostatic adenocarcinoma is unclear, although there are several factors suspected in contributing to the disease such as: age, race, hormone levels and environmental influences. The tumor can be incidentally discovered with little clinical significance or it can be an aggressive and lethal cancer. Prostate cancer is graded with the Gleason system, which divides prostate cancers into five grades. The higher the grade, the poorer the prognosis for the patient. Metastasis more than likely occurs with advanced prostate cancer and has a tendency to spread to the bone via hematogenous spread.
Back to Top
Case Study: Neuroblastoma of the Right Adrenal in a 17 Year-Old Male
Student:
Jacob Mirbegian, 2nd Year PathA, Drexel University Sacramento
Contributors
Kristin Motz, PA (ASCP), Mary Tomic, MD
About the Poster:
Neuroblastoma is the most common solid extra-cranial tumor of infancy and also the most frequently diagnosed tumor of infancy.¹ The median age of diagnosis is 18 months with approximately 40% of cases being diagnosed in infancy. Because of this, it is considered one of the most important neoplasms that may arise from the sympathetic ganglia or in close proximity to the kidneys and adrenals. A right upper quadrant mass was incidentally noted on a 17-year old male while undergoing imaging for unrelated reasons. The mass was revealed to be a neuroblastoma, despite the patient having normal urine cortisol and metanephrine levels, and a right adrenalectomy was performed. However, bone marrow biopsy later showed metastasis and the patient was subsequently started on chemotherapy.
Back to Top
A Wide Excision of Nodular Melanoma
Student:
Alina Dausey, MS, PA (ASCP)
Faculty:
Joseph Horstmann, MD and Kimberly Heightchew, MD, Paoli Hospital, Paoli, Pa.
About the Poster:
Each year there are more new cases of skin cancer than the combined incidence of cancers of the breast, prostate, lung, and colon. Basal cell carcinoma is the most common form of skin cancer and squamous cell carcinoma is the second most common form. Melanoma accounts for only 5% of all skin cancers, but it is the most deadly, accounting for 75% of all skin cancer deaths.
Contact Information
How to apply to the Pathologists' Assistant program
Back to Top