Joint Faculty Appointments
Department: Chemical and Biological Engineering
Research Interests: Molecular simulations in biophysics and materials, HIV-1 envelope structure and function, protein-ligand binding thermodynamics and kinetics
Department: Physics
Research Interests: Computational studies of confinement effects on the folding of amyloidogenic proteins, spatial correlations of neurons in the brain, firing dynamics of neuronal networks, fluid flow through porous media
Department: Physics
Research Interests: Experimental and theoretical protein dynamics, kinetics of biological self-assembly, including sickle cell and Alzheimer's disease, sickle cell testing and diagnostic devices
Department: Biology
Research Interests: Identifying and characterizing genes involved in pathogenesis of Alzheimer's disease (AD), aiming to identify novel therapeutic strategies to delay or prevent onset of AD
Department: Physics
Research Interests: Computational and experimental biophysics of protein folding and assembly, relevant to Alzheimer's and Parkinson's disease; discrete molecular dynamics of coarse-grained protein and lipid models
Research Interests: We investigate mitochondrial physiology, metabolism, and signaling in malaria parasites with a view to discover new drugs and to understand drug resistance.
Research Interests: Ligand-gated ion channels; structure-function relationships; molecular modeling; ligand-receptor interactions
Adjunct Biochemistry Faculty
Gordon J. Lutz, PhD
Research Interests: Our major research focus is to develop novel splice modulating oligomers (SMOs) as drugs to treat various serious neurological diseases, neuromuscular/muscular disorders and cancer.
Email: glutz@drexelmed.edu
Joseph Nickels, PhD
作为
Adjunct Biochemistry Faculty at Fox Chase Cancer Center
Visit Fox Chase Cancer Center
Research Interests: Genetic studies to improve screening, early detection and treatment of cancers; mechanisms underlying genetically undefined hereditary cancers; predictive biomarkers for response to chemoradiation therapy; novel strategies to screen for individuals at high risk for cancer
Research Interests: DNA repair of mismatched bases and the cellular response to DNA damage. Identification of early genetic alterations in tumorigenesis.
Research Interests: Signal transduction by small G proteins and their effectors and the role of these proteins in regulating cytoskeletal structure, tumor invasion, and metastasis; regulation of insulin signaling.
Research Interests: Goal of our research is to discover ways to improve the treatment of epithelial ovarian cancer.
Research Interests: Tumor microenvironment and tumor-stroma interactions; a primary fibroblast-derived and in vivo-like 3D system that mimics stroma progression is used to investigate both the mechanisms of matrix induced myofibroblastic differentiation (e.g., desmoplastic activation) and the tumor-associated matrix induced permissiveness that promotes tumorigenesis and cell invasion. The stroma progressive 3D system also serves as basis for a platform investigating tumor-associated matrix induced drug responsiveness.
Research Interests: Computational structural biology, including homology modeling, fold recognition, molecular dynamics simulations, statistical analysis of the PDB and bioinformatics.
Research Interests: Identifying drug survival mechanisms for novel therapeutic strategies to benefit patients. Developing organoid models for precision medicine. Determining pathways and mechanisms regulating chromatin modifiers and enhancer-promoter interactions in hematopoietic cells. Systems biology approaches to determine epigenetic plasticity and epigenome regulation.
Research Interests: Understanding points of communication between the cell cycle machinery and cell shape controls, with particular reference to how these processes are simultaneously disrupted in cancer; the HEF1, HEI10, and HEI-C proteins, which function in cell cycle-cell attachment control pathways.
Research Interests: The Johnson laboratory studies mechanisms of DNA damage detection, repair, and signaling that occur in BRCA1 mutation-containing organisms and cancers. We use a range of approaches, including cell biology, mouse genetics, and therapy resistance modeling, to understand basic biological processes and their implications for tumorigenesis and chemotherapy sensitivity.
Research Interests: The role of dysregulated methionine metabolism and human diseases; correction of mutant protein function by chaperone therapy; mouse models of human disease.
Research Interests: Understanding mechanisms of drug resistance in gastrointestinal stromal tumors (GIST); preclinical testing of novel agents/combinations in GIST patient derived xenografts (PDX); identification of biomarkers of response to targeted agents in soft tissue sarcomas
Research Interests: Epigenetic Mechanisms Driving Copy Gain, Amplifications and Drug Resistance
Research Interests: Immune regulatory pathways in human lymphoid malignancies. We are interested in the immune signaling pathways, particularly key transcriptional factors and ubiquitin-mediated signaling, required for lymphoma pathogenesis and immunotherapy. We have established an unbiased high-throughput CRISPR library screening technology to rapidly and accurately identify key pathways that are suitable for targeted therapy and immunotherapy.
Adjunct Biochemistry Faculty at the Wistar Institute
Research Interests: The lab is interested in how genomic regulatory sequences, termed enhancers, work to determine cell identity and specify blood lineages, such as monocytes/macrophages and granulocytes, from hematopoietic stem cells.
Research Interests: Dr. Schug is interested in investigating metabolic adaptation in cancer cells through the use of cell biology, biochemistry, and metabolomics.
Retired Faculty
Professor Emerita
Department: Biochemistry & Molecular Biology
Research Interests: Cellular response to DNA damage, regulation of gene expression, cellular proliferation and the cell cycle
Professor Emerita
Department: Biochemistry & Molecular Biology
Professor
Department: Biochemistry & Molecular Biology
Research Interests: Medical and graduate student education; previous research focused on structure-based drug design studies for development of immune-regulatory compounds
Marilyn Jorns, PhD
Professor Emerita
Department: Biochemistry & Molecular Biology
Research Interests: Use of structure-based drug design to develop a new class of drugs to treat heart failure, based on modulation of the gasotransmitter hydrogen sulfide; structure and mechanism of membrane-bound oxidoreductases
Gerald Soslau, PhD
Professor Emeritus
Department: Biochemistry & Molecular Biology
Research Interests: Platelet biochemistry/molecular biology and hemostasis
* Physician's practice is independent of Drexel University.
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